Programmed Cell Death-1 Inhibitor–Induced Type 1 Diabetes Mellitus
نویسندگان
چکیده
منابع مشابه
Fulminant type 1 diabetes mellitus with anti‐programmed cell death‐1 therapy
Anti-programmed cell death-1 (PD-1) antibodies are regarded as a risk factor for insulin-dependent diabetes mellitus as a side-effect. While a small number of cases have been reported, evidence remains limited. This is the first report of an Asian patient developing insulin-dependent diabetes during anti-PD-1 therapy. A 55-year-old euglycemic woman receiving nivolumab for malignant melanoma sho...
متن کامل-Cell Stress and Death in Type 1 Diabetes Mellitus
1.1 Pathophysiology of type I diabetes mellitus: Role of pro-inflammatory cytokines Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterised by the destruction of insulin-producing ┚-cells in the pancreatic islets of Langerhans (Fig.1), which is mediated by autoreactive T cells, macrophages and pro-inflammatory cytokines (Fig.2). This leads to an inability to produce sufficient in...
متن کاملNivolumab, an Anti-Programmed Cell Death-1 Antibody, Induces Fulminant Type 1 Diabetes.
Programmed cell death-1 (PD-1), an immunoreceptor, is located on T cells and pro-B cells and interacts with its ligands to inhibit T cell activation and proliferation, thereby promoting immunological self-tolerance. Nivolumab, an anti-PD1 antibody, blocks PD-1 and can restore anticancer immune responses by abrogating PD-1 pathway-mediated T-cell inhibition. Autoimmune adverse events are expecte...
متن کامل[Programmed cell death 1 (PDCD1) gene polymorphisms and type 1 diabetes in Chilean children].
BACKGROUND Programmed cell death 1 (PDCD-1) immune-receptor is a key element in the negative regulation of peripheral tolerance in T cells. Several polymorphisms of this gene have been described and it is linked with susceptibility to autoimmune diseases like Lupus and Multiple Sclerosis. AIM To analyze four gene polymorphisms of PDCD-1 gene and explore its possible contribution as a suscepti...
متن کاملType 1 diabetes mellitus.
1. All children with type 1 diabetes mellitus (T1DM) should have their blood sugar managed with basal-bolus insulin treatment by either multiple daily injections or an insulin pump. 2. All children with T1DM should have access to a pediatric endocrinologist with a diabetes management team with resources to support patients and families. 3. All children with T1DM should be monitored for symptoms...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2018
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2018-00728